翻訳と辞書 Words near each other ・ Herşey Sensin ・ Herşey Yolunda ・ Herşeye Rağmen ・ Heršpice ・ Herța River ・ HES ・ Hes family bhlh transcription factor 2 ・ Hes Games ・ HES School of Economics and Business ・ HES Unidaptor ・ HES1 ・ HES3 ・ Hes3 signaling axis ・ HES5 ・ HES6 ・ HES7 gene ・ HESA ・ Hesa Air Base ・ Hesa Awal Behsood District ・ Hesa Awal Kohistan District ・ HESA Azarakhsh ・ HESA Dorna ・ Hesa Duwum Kohistan District ・ HESA Saeqeh ・ HESA Shafaq ・ HESA Shahed 278 ・ HESA Shahed 285 ・ Hesagi ・ Hesaka Station ・ Hesaki Lighthouse Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HES7 gene ： ウィキペディア英語版 HES7 gene HES 7 Gene, Hes family bHLH transcription factor 7 also known as HES7 or bHLHb37 is a protein coding mammalian gene.〔Murphy M, Brown G, Wallin C, Tatusova T, Pruitt K, Murphy T, Maglott D (2015). “Gene Help: Integrated Access to Genes of Genomes in the Reference Sequence Collection”.〕 Hes7 has a basic helix-loop-helix structure, and encodes a member of the hairy and enhancer of split family of bHLH transcription factors. ==Function== The HES7 codes the HES7 protein which works in tandem with NOTCH1 in the Notch Pathway in development of fetal somites. Specifically, HES7 is responsible for somite segmentation, or the separation of future vertebrae in an anterior posterior fashion.〔Kageyama R, Ohtsuka T, Kobayashi T (2007). “The Hes gene family: repressors and oscillators that orchestrate embryogenesis”. Development 134 (7): 1243-1251.〕 Somites will go on to be vertebrae, ribs, or the dermis, and are regulated by the oscillatory activity of both HES7 and NOTCH 1.〔Sparrow DB, Chapman G, Turnpenny PD, Dunwoodie SL (2007). “Disruption of the somatic molecular clock causes abnormal vertebral segmentation”. Birth Defects Res C Embryo Today 81 (2): 93-110.〕 HES7 acts antagonistically to control the activity of NOTCH1, and in the absence of HES7, somites fuse which results in fused vertebrae or ribs. The HES7 protein turns off (represses) the activity of genes in the Notch pathway, such as downstream effector Lunatic Fringe, an important transcription factor in the clock wavefront mechanism. Mutation of the HES7 gene causes spondylocostal dysostosis, which is characterized by abnormal development of bones in the spine and ribs. Improper segmentation due to the mutation is common.〔Sparrow DB, Guillen-Navarro E, Fatkin D, Dunwoodie SL (2008). “Mutation of Hairy-and-enhancer-of-Split-7 in humans causes spondylocostal dysotosis”. Human Mol Genet 17 (23): 3761-3766.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HES7 gene」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.